Structure of PDB 8czq Chain A Binding Site BS02

Receptor Information
>8czq Chain A (length=655) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKS
QPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDRE
GEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQE
TRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRS
AAYWDILAKLTFSARLTAVAGRRVATGRDFDSLGTLRKEVIVLDEGSATA
LAADGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIA
QRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRK
VKQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMA
DARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVRLPHLTPGQRL
DIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGY
VHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNER
RTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDD
THGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAE
ELFAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8czq The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		Y299 R301 Y304 R318 R460 T518 K553 G554 S555
Binding residue
(residue number reindexed from 1)		Y268 R270 Y273 R287 R427 T469 K504 G505 S506
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:8czq, PDBe:8czq, PDBj:8czq
PDBsum8czq
PubMed36583363
UniProtP9WG49|TOP1_MYCTU DNA topoisomerase 1 (Gene Name=topA)

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