Structure of PDB 8czk Chain A Binding Site BS02
Receptor Information
>8czk Chain A (length=400) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
HMAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMER
GLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCL
TKRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPN
EMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNF
TAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVD
YVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYL
CDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRAC
KFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
8czk Chain A Residue 500 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
8czk
The mechanism of thia-Michael addition catalyzed by LanC enzymes.
Resolution
1.91 Å
Binding residue
(original residue number in PDB)
C276 C322 H323
Binding residue
(residue number reindexed from 1)
C277 C323 H324
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.5.1.18
: glutathione transferase.
Gene Ontology
Molecular Function
GO:0004364
glutathione transferase activity
GO:0004930
G protein-coupled receptor activity
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016740
transferase activity
GO:0017124
SH3 domain binding
GO:0043295
glutathione binding
GO:0046872
metal ion binding
GO:0050750
low-density lipoprotein particle receptor binding
Biological Process
GO:0005975
carbohydrate metabolic process
GO:0007186
G protein-coupled receptor signaling pathway
GO:0031179
peptide modification
GO:1990748
cellular detoxification
Cellular Component
GO:0005737
cytoplasm
GO:0005886
plasma membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8czk
,
PDBe:8czk
,
PDBj:8czk
PDBsum
8czk
PubMed
36634136
UniProt
O43813
|LANC1_HUMAN Glutathione S-transferase LANCL1 (Gene Name=LANCL1)
[
Back to BioLiP
]