Structure of PDB 8cy2 Chain A Binding Site BS02

Receptor Information
>8cy2 Chain A (length=544) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKKESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLL
EKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLRE
YIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNE
DICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEK
CKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNIN
KYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRK
WYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEE
YLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRD
NNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cy2 Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		H171 K172 K179 D192 K193 I349 C352 D353 K378 K380 R425 Q438 W439 Y455 A473 K515
Binding residue
(residue number reindexed from 1)		H138 K139 K146 D159 K160 I316 C319 D320 K345 K347 R392 Q405 W406 Y422 A440 K482
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cy2, PDBe:8cy2, PDBj:8cy2
PDBsum8cy2
PubMed36581322
UniProtQ183J3

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