Structure of PDB 8cro Chain A Binding Site BS02

Receptor Information
>8cro Chain A (length=900) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGVI
DPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCRECG
RIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAPQ
YPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGLD
PEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINNR
LKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKTL
AQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMELT
VPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLAN
QLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLAV
CPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGGI
QDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPLW
SGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRKL
AYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQV
TKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYKR
GELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAKT
GARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKGF
VVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDLK
VEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMRG
Ligand information
Receptor-Ligand Complex Structure
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PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R423 D460 D462
Binding residue
(residue number reindexed from 1)		R422 D459 D461
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M4

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