Structure of PDB 8clj Chain A Binding Site BS02

Receptor Information
>8clj Chain A (length=542) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRA
LATHPGISFYEEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPI
HMILENKDGIQGSCRYFKERKNITNDIRTKSLQPRCTMVEAFDRWGKKLI
IVASQAMRYRALIGQEGDPDLKLPDFSYCILERLGRSRWQGELQRDLHTT
AFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSILLLLNRFHVD
RRSKYDILMEKLSVMLSTRTNHIETLGKLREELGLCERTFKRLYQYMLNA
GLAKVVSLRLQEIHVMVRCLKLLKTVPPVDIVFERDMLTQTYDLIERRGT
KGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDEGRQRTTKYISC
VFAEESDLSRQYQREKARSELLTTVSLAAVIEEVRETYRLLKRRNLIIEA
VTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRL
YRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISN
Ligand information
Receptor-Ligand Complex Structure
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PDB8clj Structural insights into human TFIIIC promoter recognition.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K208 Y211 Q236 R292 Y296 L398 R401 M402 R409 R422 R424 T652 C655 R661
Binding residue
(residue number reindexed from 1)		K208 Y211 Q236 R292 Y296 L367 R370 M371 R378 R391 R393 T478 C481 R487
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0009303 rRNA transcription
GO:0009304 tRNA transcription
GO:0042791 5S class rRNA transcription by RNA polymerase III
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016020 membrane
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8clj, PDBe:8clj, PDBj:8clj
PDBsum8clj
PubMed37418517
UniProtQ12789|TF3C1_HUMAN General transcription factor 3C polypeptide 1 (Gene Name=GTF3C1)

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