Structure of PDB 8c9s Chain A Binding Site BS02

Receptor Information

>8c9s Chain A (length=223) Species: 227882 (Streptomyces avermitilis MA-4680 = NBRC 14893) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SESQQLWDDVDDYFTTLLAPEDEALTAALRDSDAAGLPHINVAPNQGKLL
QLLAEIQGARRILEIGTLGGYSTIWLGRALPRDGRLISFEYDAKHAEVAR
RNLARAGLDGISEVRVGPALESLPKLADERPEPFDLVFIDADKVNNPHYV
EWALKLTRPGSLIVVDNVVRGGGVTDAGSTDPSVRGTRSALELIAEHPKL
SGTAVQTVGSKGYDGFALARVLP

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8c9s Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8c9s Structural Characterization and Extended Substrate Scope Analysis of Two Mg 2+ -Dependent O-Methyltransferases from Bacteria.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	D141 D167 N168
Binding residue (residue number reindexed from 1)	D140 D166 N167
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0032259	methylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:8c9s, PDBe:8c9s, PDBj:8c9s
PDBsum	8c9s
PubMed	36942619
UniProt	Q82B68

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