Structure of PDB 8c8j Chain A Binding Site BS02

Receptor Information
>8c8j Chain A (length=698) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLNNLLLNDYWVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFI
ALNANQIDTIKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFL
DTYTLPRLNQEEVESLNRPITGSEIVAIINSLPTKKSPGPDGFTAEFYQR
YKEELVPFLLKLFQSIEKEGILPNSFYEASIILIPKPGRDTTKKENFRPI
SLMNIDAKILNKILANRIQQHIKKLIHHDQVGFIPGMQGWFNIRKSINVI
QHINRAKDKNHMIISIDAEKAFDKIQQPFMLKTLNKLGIDGTYFKIIRAI
YDKPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQEK
EIKGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKI
NVQKSQAFLYTNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKE
NYKPLLKEIKEETNKWPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMTF
FTELEKTTLKFIWNQTLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPS
YNYLIFDKPEKNGKDSLFNKWCWENWLAICRKLKLDPFLTPYTKINSRWI
KDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDKWDLI
KLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQIYH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c8j Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Resolution2.1 Å
Binding residue
(original residue number in PDB)		K469 S470 I515 I517 I533 L535 K541 K545 F566 I567 P568 M570 Q571 I642 N644 G645 G660 P662 Y878 K1047 G1048 I1050 S1051
Binding residue
(residue number reindexed from 1)		K136 S137 I182 I184 I200 L202 K208 K212 F233 I234 P235 M237 Q238 I309 N311 G312 G327 P329 Y523 K683 G684 I686 S687
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
External links
PDB RCSB:8c8j, PDBe:8c8j, PDBj:8c8j
PDBsum8c8j
PubMed38096902
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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