Structure of PDB 8c5u Chain A Binding Site BS02

Receptor Information
>8c5u Chain A (length=919) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGEGMRTARAVISV
GKAIEMEFRSEQVLKKILWPQSIRARIGSVLISMLIQVAKVSVQGVDPVT
KAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQPQLL
PMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDIDRVY
DGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAPPKN
SDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYFPHN
LDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLSNLF
GFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALATCFE
LNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLVPSD
KPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTNVYG
VTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAHLIQ
DWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQPYR
EESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHMLLS
AAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLRLKE
EFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIYFEK
KRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALEGMSVLLPLRLPEI
PPKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8c5u Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.62 Å
Binding residue
(original residue number in PDB)		L519 N520 R530 A532 Y638 S644 K645 L646 R699 C801 D802 R827 Y831 P835 Y1022 V1024 T1025 Y1122 Q1129 Q1135 T1136 F1138 I1139 R1151 R1152
Binding residue
(residue number reindexed from 1)		L134 N135 R142 A144 Y215 S221 K222 L223 R276 C378 D379 R404 Y408 P412 Y599 V601 T602 Y699 Q706 Q712 T713 F715 I716 R728 R729
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c5u, PDBe:8c5u, PDBj:8c5u
PDBsum8c5u
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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