Structure of PDB 8c4u Chain A Binding Site BS02

Receptor Information
>8c4u Chain A (length=1260) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNITTV
LDKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSL
HSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDG
DSQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYA
IRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFER
PFKSSLEVYIYYNIKSLLVALAQNNKSGVYPSFMSRIVYKHYRSLISEVT
TCFFLFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMW
ELRANAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPY
FSQTRNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEE
TREQKAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISE
EYISYGGEKKILAIQGALEKALRWASGESFIELSKFIRMKRKLMYVSADA
TKWSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKL
RNYIDSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMS
LLFKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQ
IQAGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLS
TFFEGCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQ
VAQLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSI
MELATAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLGQFSFI
GVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIPKGRDNLLIYLV
RKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVTFREVLAAAN
SFAENYSATSQDMDLFQTLTSCTFSKEYAWKDFLNGIHCDVIPTKQVQRA
KVARTFTAVIGYKFAVTVEEMSDVLDTARVVIVQGNVEGTAEAICRYWLK
SMSLVKTIRV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c4u Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		T374 L492 K496 S517 E519 V520 K831 G832 R880 V882 Y885 F894 F895 I896 G927 G928 E929 G1059 N1062 F1341 T1342 K1344 T1397 Q1399 S1400 Q1403 R1407
Binding residue
(residue number reindexed from 1)		T149 L242 K246 S267 E269 V270 K560 G561 R609 V611 Y614 F623 F624 I625 G656 G657 E658 G786 N789 F1057 T1058 K1060 T1113 Q1115 S1116 Q1119 R1123
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c4u, PDBe:8c4u, PDBj:8c4u
PDBsum8c4u
PubMed37221161
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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