Structure of PDB 8c41 Chain A Binding Site BS02

Receptor Information
>8c41 Chain A (length=720) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGEL
EELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARA
ERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVFHMSNIQNMSLEDIMGER
FGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSV
GNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAM
RYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNG
STGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTG
AIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKA
NLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLF
KYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKE
KAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQA
EAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKE
LREVKKKFATPRLSSLEDTA
Ligand information
Receptor-Ligand Complex Structure
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PDB8c41 The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.
Resolution2.393 Å
Binding residue
(original residue number in PDB)		K458 N461 K464 H513 V626 R629 R630 Y1118 I1170 S1171 G1173 Y1174 A1175 R1235 N1326
Binding residue
(residue number reindexed from 1)		K44 N47 K50 H99 V212 R215 R216 Y352 I404 S405 G407 Y408 A409 R469 N560
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c41, PDBe:8c41, PDBj:8c41
PDBsum8c41
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC)

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