Structure of PDB 8c2z Chain A Binding Site BS02

Receptor Information

>8c2z Chain A (length=334) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELV
AIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLC
LVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIH
CDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG
TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML
DQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVGHSPAD
YLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

8c2z Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8c2z Structural perspective on the design of selective DYRK1B inhibitors
Resolution	1.91 Å
Binding residue (original residue number in PDB)	D239 D259
Binding residue (residue number reindexed from 1)	D152 D172
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.12.1: dual-specificity kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation
GO:0046777	protein autophosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:8c2z, PDBe:8c2z, PDBj:8c2z
PDBsum	8c2z
PubMed
UniProt	Q9Y463\|DYR1B_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Gene Name=DYRK1B)

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