Structure of PDB 8c05 Chain A Binding Site BS02

Receptor Information

>8c05 Chain A (length=305) Species: 2051956 (Methylotenera sp.)

QYLLEAIVRDARDGITISDCSRPDNPLVFVNDAFTRMTGYDAEEVIGKNC
RFLQRGDINLSAVHTIKIAMLTHEPCLVTLKNYRKDGTIFWNELSLTPII
NKNGLITHYLGIQKDVSAQVILNQTLHEENSNKEMLEYLVNIDALTGLHN
RRFLEDQLVIQWKLASRHINTITIFMIDIDYFKAFNDTYGHTAGDEALRT
IAKTLNNCFMRGSDFVARYGGEEFTILAIGMTELQAHEYSTKLVQKIENL
NIHHKGSPLGHLTISLGYSQANPQYHNDQNLVIEQADRALYSAKVEGKNR
AVAYR

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8c05 Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c05 Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D185 I186 E229
• Binding residue (residue number reindexed from 1): D178 I179 E222
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.65: diguanylate cyclase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0046872 metal ion binding
• GO:0052621 diguanylate cyclase activity

Biological Process

• GO:0043709 cell adhesion involved in single-species biofilm formation
• GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:8c05, PDBe:8c05, PDBj:8c05
• PDBsum: 8c05
• PubMed: 37531459
• UniProt: A0A2S5LZS0