Structure of PDB 8bdy Chain A Binding Site BS02

Receptor Information

>8bdy Chain A (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRD
IGKPEVEYDCDNLQHSQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPAS
IPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFN
EMMKVVQVYADDSEVAQAGKAVALYFEDKLTEIYSDRTFA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8bdy Chain A Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8bdy Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Resolution	3.05 Å
Binding residue (original residue number in PDB)	C902 C905 C931
Binding residue (residue number reindexed from 1)	C19 C22 C48
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

External links

PDB	RCSB:8bdy, PDBe:8bdy, PDBj:8bdy
PDBsum	8bdy
PubMed	36430693
UniProt	Q9UPN9\|TRI33_HUMAN E3 ubiquitin-protein ligase TRIM33 (Gene Name=TRIM33)

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