Structure of PDB 8bc0 Chain A Binding Site BS02

Receptor Information
>8bc0 Chain A (length=680) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEFEEFNGKPDSLFFTDGQRRIDFILVYENEKQKRKRQAYESNLICHGLQ
LEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHSFFNPATRSRIVYFILSR
INRLVSSGIYKAAFPLHDCRFSERYLLYREWAHPRSIYKKQPLDLIRKYY
GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDI
GGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTL
FLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCKCIRVTLCASAVFFW
ILLIIASVIGIIVYRLSVFIVFSTTPQMATSITASIISAIIIMILNTIYE
KVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG
YPGDPVYLYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIAEVLLPWVMN
LIGRYKRKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPL
APLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAV
VTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNIT
DFKNENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFII
VMEHIIYSVKFFISYAIPDVSKITKSKIKR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8bc0 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8bc0 Structural basis for the activation of the lipid scramblase TMEM16F.
Resolution3.09 Å
Binding residue
(original residue number in PDB)		E624 E667 E699 D703
Binding residue
(residue number reindexed from 1)		E442 E480 E512 D516
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0007596 blood coagulation
GO:0017121 plasma membrane phospholipid scrambling
GO:0030501 positive regulation of bone mineralization
GO:0032060 bleb assembly
GO:0034220 monoatomic ion transmembrane transport
GO:0034767 positive regulation of monoatomic ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035630 bone mineralization involved in bone maturation
GO:0043065 positive regulation of apoptotic process
GO:0045332 phospholipid translocation
GO:0045794 negative regulation of cell volume
GO:0051649 establishment of localization in cell
GO:0060078 regulation of postsynaptic membrane potential
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061588 calcium activated phospholipid scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:0070588 calcium ion transmembrane transport
GO:0090026 positive regulation of monocyte chemotaxis
GO:1902476 chloride transmembrane transport
GO:1903766 positive regulation of potassium ion export across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0097060 synaptic membrane
GO:0098981 cholinergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bc0, PDBe:8bc0, PDBj:8bc0
PDBsum8bc0
PubMed36335104
UniProtQ6P9J9|ANO6_MOUSE Anoctamin-6 (Gene Name=Ano6)

[Back to BioLiP]