Structure of PDB 8b9n Chain A Binding Site BS02

Receptor Information
>8b9n Chain A (length=239) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSVYSGVETLGKELFMYF
GHRALRIHFGMKGSILINPRSPALAVQLTRDLICFYDSSVELRNSVESQQ
RVREMEELDICSPKFSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIK
NEALFDSGLHPAVKVCQLSDKQARHLVKMTRDFSILFYRCCKAGSAISKH
CKVYKRPNCGQCHSKITVCRFGENSRMTYFCPHCQKDGL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8b9n Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9n Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C255 C258 C277 C280
Binding residue
(residue number reindexed from 1)		C209 C212 C231 C234
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8b9n, PDBe:8b9n, PDBj:8b9n
PDBsum8b9n
PubMed
UniProtQ8K203|NEIL3_MOUSE Endonuclease 8-like 3 (Gene Name=Neil3)

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