Structure of PDB 8b77 Chain A Binding Site BS02

Receptor Information
>8b77 Chain A (length=1110) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNVKVDAKHLIEDIREYDVPYHVRVSIDK
DIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQ
IMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVA
LLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPD
AEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPE
LMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDET
LRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGH
VESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKV
TNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPD
SIKAERDCASCDFKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPL
SYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKS
FRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVI
LVSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDT
DGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQEL
KDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDG
SLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRW
LDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDF
LGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRW
TLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEH
PDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b77 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 V558 R686 V825 S829 G832 M835 R836 K837 I965 K966 K967 R968 R988 T1103 Y1145 R1149 K1156
Binding residue
(residue number reindexed from 1)		K453 G454 T455 G456 T457 T495 Y496 G498 V501 R625 V749 S753 G756 M759 R760 K761 I889 K890 K891 R892 R912 T1027 Y1069 R1073 K1080
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b77, PDBe:8b77, PDBj:8b77
PDBsum8b77
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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