Structure of PDB 8b6l Chain A Binding Site BS02

Receptor Information
>8b6l Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPFYWM
RVILELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMII
TIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGY
GLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATR
TDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSYNTY
PIKLFYTSNIPIILQSALVSNLYVISQMLSLLGTWSDRAYPVGGLCYYLS
PPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKE
QQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTG
ILLAVTIIYQYFEIFVKEQSEVGSM
Ligand information
>8b6l Chain D (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8b6l Visualization of translation and protein biogenesis at the ER membrane.
Resolution7.6 Å
Binding residue
(original residue number in PDB)		M136 N294
Binding residue
(residue number reindexed from 1)		M113 N271
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b6l, PDBe:8b6l, PDBj:8b6l
PDBsum8b6l
PubMed36697828
UniProtP61619|S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

[Back to BioLiP]