Structure of PDB 8b67 Chain A Binding Site BS02

Receptor Information
>8b67 Chain A (length=1085) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGW
LTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESR
VNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQ
LFEARKLLRPILQDNQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKDIRV
GKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIMMI
SYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQR
FFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGE
YKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTP
YAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKG
TGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESL
EAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFE
EIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQPDSIKA
ERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNVLTFDELSYA
DQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRD
RRYEFKGLAKTMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGIT
CLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKK
LYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPY
KAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQS
DIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENR
SMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNA
PVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERL
GSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8b67 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 V558 R686 N828 S829 Y831 G832 M835 R836 I965 K966 K967 R988 K1063 T1103 Y1145 R1149 K1156
Binding residue
(residue number reindexed from 1)		K449 G450 T451 G452 T453 T491 Y492 G494 G495 V497 R615 N728 S729 Y731 G732 M735 R736 I865 K866 K867 R888 K963 T1003 Y1045 R1049 K1056
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b67, PDBe:8b67, PDBj:8b67
PDBsum8b67
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

[Back to BioLiP]