Structure of PDB 8atw Chain A Binding Site BS02

Receptor Information
>8atw Chain A (length=922) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAV
ISVGKAIEMEFRSEQVLKKILWPQSIRARIGSVLISMLIQVAKVSVQGVD
PVTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQP
QLLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDID
RVYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAP
PKNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYF
PHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLS
NLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALAT
CFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLV
PSDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTN
VYGVTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAH
LIQDWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQ
PYREESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHM
LLSAAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLR
LKEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIY
FEKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALEGMSVLLPLRL
PEIPPKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8atw Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.62 Å
Binding residue
(original residue number in PDB)		T522 G523 R533 Y638 S644 K645 G647 R699 S798 F826 R827 Y831 P835 T1019 Y1022 G1023 V1024 T1025 V1027 Y1122 K1127 Q1129 Q1135 T1136 V1137 F1138 K1239
Binding residue
(residue number reindexed from 1)		T137 G138 R148 Y218 S224 K225 G227 R279 S378 F406 R407 Y411 P415 T599 Y602 G603 V604 T605 V607 Y702 K707 Q709 Q715 T716 V717 F718 K819
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8atw, PDBe:8atw, PDBj:8atw
PDBsum8atw
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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