Structure of PDB 8atv Chain A Binding Site BS02

Receptor Information
>8atv Chain A (length=923) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAV
ISVGKAIEMEFRSEQVLKSEKILWPQSIRARIGSVLISMLIQVAKVSVQG
VDPVTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASV
QPQLLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGD
IDRVYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPP
APPKNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKL
YFPHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIH
LSNLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQAL
ATCFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVN
LVPSDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVM
TNVYGVTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHS
AHLIQDWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPI
VQPYREESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDAS
HMLLSAAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLV
LRLKEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADE
IYFEKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALGMSVLLPLR
LPEIPPKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8atv Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.39 Å
Binding residue
(original residue number in PDB)		G523 R530 R533 Y638 S644 K645 G647 K701 R827 P835 T1019 Y1022 G1023 V1024 T1025 V1027 Q1032 Y1122 Q1129 Q1135 T1136 V1137 F1138 P1159 H1163
Binding residue
(residue number reindexed from 1)		G138 R145 R148 Y220 S226 K227 G229 K283 R409 P417 T601 Y604 G605 V606 T607 V609 Q614 Y704 Q711 Q717 T718 V719 F720 P741 H745
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8atv, PDBe:8atv, PDBj:8atv
PDBsum8atv
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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