Structure of PDB 8asb Chain A Binding Site BS02

Receptor Information
>8asb Chain A (length=1715) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESISGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDYRRFKPALSSS
ARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNL
LTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWS
LWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSL
GIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLN
SIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRY
TQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPF
SLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALG
EMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIA
QRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKE
YHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGG
LREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLK
SARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAI
SMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKG
RTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGV
VDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSS
EKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDY
SNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISD
PDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEISVMVY
WGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAANKKELLLKLAEKVH
SPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSQKASLIKLLMMSSISAM
KHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHLTGKFVERNIVRSRIDC
KAEDLVSEVWFGLKRTKLGPRLLKEEWDKLRASFAWLSTDPSETLRDGPF
LSHVQFRNFIAHVDSRSVRLLGAPTTISQVVRMNFFPGFSLEKSRTMTLC
LLSNYLSSRGGSILDQIERAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVW
TGVMEDTHVQILIDGDGTSNWLEEIRLSSDARLYDVIESIRRLCDDLGIN
NRVASAYRGHCMVRLSGFKIKPASRTDGCPVRIMPDEVKMRVRGDILNLS
VTIQEGRVMNILSYR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8asb Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K533 H535 R537 S560 S561 E759 K849 A850 H870 R871 F911 N914 I922 Y923 V924 R930 R1031 Q1080 G1081 W1342 K1346 K1347 Y1348 K1401 G1402 H1403 R1407
Binding residue
(residue number reindexed from 1)		K515 H517 R519 S542 S543 E741 K831 A832 H852 R853 F893 N896 I904 Y905 V906 R912 R1013 Q1062 G1063 W1301 K1305 K1306 Y1307 K1360 G1361 H1362 R1366
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asb, PDBe:8asb, PDBj:8asb
PDBsum8asb
PubMed36651274
UniProtU3GU88

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