Structure of PDB 8as7 Chain A Binding Site BS02 |
| >8as7 Chain A (length=1575) Species: 992210 (SFTS virus AH12)
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MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDS
GFGSLMDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISAKITYRR
FKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIG
DFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNL
SSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKS
SSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLV
NLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTE
EIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCM
VRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEE
STELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAAC
SSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWEL
YSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICL
FKKNQHGGLREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNS
IIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKF
HRFIWAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNR
DVSWMDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGY
MGESISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLN
PLFGIYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEA
LASRQEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGT
FMGMLISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYF
NEIQGKGTLSHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRR
AANKKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSQ
KASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHL
TGKFVVRERNIVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTKLGPRLL
KEEWDKLRASFAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKSRSVRLL
GAPVKKVTTISQVVRMNFFPGFSLE |
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| PDB | 8as7 Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. |
| Resolution | 2.6 Å |
Binding residue
(original residue number in PDB) | K533 H535 R537 S560 S561 K849 A850 H870 R871 F911 K913 N914 I922 Y923 R930 V952 P955 R1031 Q1080 G1081 F1085 W1342 G1343 R1345 K1346 K1347 Y1348 K1401 G1402 H1403 R1407 |
Binding residue
(residue number reindexed from 1) | K523 H525 R527 S550 S551 K839 A840 H860 R861 F901 K903 N904 I912 Y913 R920 V942 P945 R1021 Q1070 G1071 F1075 W1317 G1318 R1320 K1321 K1322 Y1323 K1376 G1377 H1378 R1382 |
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| Enzyme Commision number |
2.7.7.48: RNA-directed RNA polymerase. |
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