Structure of PDB 8ap1 Chain A Binding Site BS02

Receptor Information
>8ap1 Chain A (length=918) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKGLNKVDT
NRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAVISVGKA
IEMEFRSEQVLKSESQAKILWPQSIRARIGSVLISMLIQVAKVSVQGVDP
VTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQPQ
LLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDIDR
VYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAPP
KNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYFP
HNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLSN
LFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALATC
FELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLVP
SDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTNV
YGVTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAHL
IQDWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQP
YREESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHML
LSAAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLRL
KEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIYF
EKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDAMSVLLPLRLPEIP
PKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8ap1 Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.47 Å
Binding residue
(original residue number in PDB)		I536 Y638 S644 K645 G647 R699 F826 R827 T1019 G1023 V1024 T1025 Q1032 Y1122 Q1129 Q1135 T1136 F1138 R1151
Binding residue
(residue number reindexed from 1)		I145 Y217 S223 K224 G226 R278 F405 R406 T598 G602 V603 T604 Q611 Y701 Q708 Q714 T715 F717 R730
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ap1, PDBe:8ap1, PDBj:8ap1
PDBsum8ap1
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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