Structure of PDB 8aht Chain A Binding Site BS02

Receptor Information
>8aht Chain A (length=140) Species: 5833 (Plasmodium falciparum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTEEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMI
NEIDTDGNGTIDFPEFLTLMARKLKDELIEAFRVFDRDGDGYISADELRH
VMTNLGEKLTNEEVDEMIREADIDGDGQINYEEFVKMMIA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8aht Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8aht Structures of calmodulin-melittin complexes show multiple binding modes lacking classical anchoring interactions.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D20 D22 D24 T26 E31
Binding residue
(residue number reindexed from 1)		D18 D20 D22 T24 E29
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0008047 enzyme activator activity
GO:0046872 metal ion binding
GO:0061891 calcium ion sensor activity
Cellular Component
GO:0005737 cytoplasm
GO:0020007 apical complex

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:8aht, PDBe:8aht, PDBj:8aht
PDBsum8aht
PubMed36906144
UniProtP62203|CALM_PLAF7 Calmodulin (Gene Name=CAM)

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