Structure of PDB 8agb Chain A Binding Site BS02

Receptor Information
>8agb Chain A (length=642) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CVLSVFQTILKLVIFVAIFGAAISSRLFAVIKFESIIHEFDPWFNYRATK
YLVNNSFYKFLNWFDDRTWYPLGRVTGGTLYPGLMTTSAFIWHALRNWLG
LPIDIRNVCVLFAPLFSGVTAWATYEFTKEIKDASAGLLAAGFIAIVPGY
ISRSVAGSYDNEAIAITLLMVTFMFWIKAQKTGSIMHATCAALFYFYMVS
AWGGYVFITNLIPLHVFLLILMGRYSSKLYSAYTTWYAIGTVASMQIPFV
GFLPIRSNDHMAALGVFGLIQIVAFGDFVKGQISTAKFQPVSWPAFFFDT
HFLIWLFPAGVFLLFLDLKDEHVFVIAYSVLCSYFAGVMVRLMLTLTPVI
CVSAAVALSKIFDIYLDFKIKPAALLAKLIVSGSFIFYLYLFVFHSTWVT
RTAYSSPSVVLPKLALIDDFREAYYWLRMNSDEDSKVAAWWDYGYQIGGM
ADRTTLVDNNTWNNTHIAIVGKAMASPEEKSYEILKEHDVDYVLVIFGGL
IGFGGDDINKFLWMIRISEGIWPEEIKERDFYTAEGEYRVDARASETMRN
SLLYKMSYKDFPQLFNGGQATDRVRQQMITPLDVPPLDYFDEVFTSENWM
VRIYQLKKDDAQGRTLRDVGELTRSSTKTRRSIKRPELGLRV
Ligand information
Ligand IDELU
InChIInChI=1S/C20H38O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,20H,6-8,10,12,14-16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+/t20-/m1/s1
InChIKeySJMIVFIDXGVUHA-WKWVIOPWSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C[C@H](CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)CCOP(=O)(O)OP(=O)(O)O
OpenEye OEToolkits 2.0.7CC(CCC=C(C)CCC=C(C)CCC=C(C)C)CCOP(=O)(O)OP(=O)(O)O
CACTVS 3.385C[CH](CCO[P](O)(=O)O[P](O)(O)=O)CCC=C(C)CCC=C(C)CCC=C(C)C
CACTVS 3.385C[C@@H](CCO[P](O)(=O)O[P](O)(O)=O)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C
FormulaC20 H38 O7 P2
Namephosphono [(3~{R},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate
ChEMBL
DrugBank
ZINC
PDB chain8agb Chain A Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8agb Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		W208 F213 N216 F398 R404
Binding residue
(residue number reindexed from 1)		W202 F207 N210 F335 R341
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.99.18: dolichyl-diphosphooligosaccharide--protein glycotransferase.
Gene Ontology
Molecular Function
GO:0004576 oligosaccharyl transferase activity
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8agb, PDBe:8agb, PDBj:8agb
PDBsum8agb
PubMed36435935
UniProtP39007|STT3_YEAST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (Gene Name=STT3)

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