Structure of PDB 8abp Chain A Binding Site BS02
Receptor Information
>8abp Chain A (length=305) Species:
562
(Escherichia coli) [
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NLKLGFLVKQPEEPWFQTEWKFADKAGKDLGFEVIKIAVPDGEKTLNAID
SLAASGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKGKPMD
TVPLVMLAATKIGERQGQELYKEMQKRGWDVKESAVMAITANELDTARRR
TTGSMDALKAAGFPEKQIYQVPTKSNDIPGAFDAANSMLVQHPEVKHWLI
VGMNDSTVLGGVRATEGQGFKAADIIGIGINGVDAVSELSKAQATGFYGS
LLPSPDVHGYKSSEMLYNWVAKDVEPPKFTEVTDVVLITRDNFKEELEKK
GLGGK
Ligand information
Ligand ID
GAL
InChI
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKey
WQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
Software
SMILES
CACTVS 3.370
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2
C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370
OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01
OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2
C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
Formula
C6 H12 O6
Name
beta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBL
CHEMBL300520
DrugBank
ZINC
ZINC000002597049
PDB chain
8abp Chain A Residue 308 [
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Receptor-Ligand Complex Structure
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PDB
8abp
Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Resolution
1.49 Å
Binding residue
(original residue number in PDB)
K10 E14 W16 D89 D90 L108 R151 N232
Binding residue
(residue number reindexed from 1)
K9 E13 W15 D88 D89 L107 R150 N231
Annotation score
4
Binding affinity
MOAD
: Kd=0.01uM
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0015407
ABC-type monosaccharide transporter activity
GO:0030246
carbohydrate binding
GO:0048029
monosaccharide binding
Biological Process
GO:0042882
L-arabinose transmembrane transport
Cellular Component
GO:0016020
membrane
GO:0030288
outer membrane-bounded periplasmic space
GO:0042597
periplasmic space
GO:0055052
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8abp
,
PDBe:8abp
,
PDBj:8abp
PDBsum
8abp
PubMed
2069949
UniProt
P02924
|ARAF_ECOLI L-arabinose-binding periplasmic protein (Gene Name=araF)
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