Structure of PDB 8a8m Chain A Binding Site BS02

Receptor Information
>8a8m Chain A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK
LSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL
VTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPS
NLAVNEDCELKILDFGLARHTDDEMVGYVATRWYRAPEIMLNWMHYNQTV
DIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES
ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA
HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8a8m Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a8m Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		D168 L171
Binding residue
(residue number reindexed from 1)		D164 L167
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0051525 NFAT protein binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0000165 MAPK cascade
GO:0000902 cell morphogenesis
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001890 placenta development
GO:0002021 response to dietary excess
GO:0002062 chondrocyte differentiation
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0006006 glucose metabolic process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006974 DNA damage response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
GO:0007519 skeletal muscle tissue development
GO:0010628 positive regulation of gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019395 fatty acid oxidation
GO:0030168 platelet activation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031281 positive regulation of cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032735 positive regulation of interleukin-12 production
GO:0032868 response to insulin
GO:0033554 cellular response to stress
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0035994 response to muscle stretch
GO:0038066 p38MAPK cascade
GO:0042307 positive regulation of protein import into nucleus
GO:0042770 signal transduction in response to DNA damage
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046323 D-glucose import
GO:0046326 positive regulation of D-glucose import
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048863 stem cell differentiation
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071356 cellular response to tumor necrosis factor
GO:0071479 cellular response to ionizing radiation
GO:0071493 cellular response to UV-B
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090398 cellular senescence
GO:0090400 stress-induced premature senescence
GO:0098586 cellular response to virus
GO:0099179 regulation of synaptic membrane adhesion
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1901741 positive regulation of myoblast fusion
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000922 spindle pole
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0034774 secretory granule lumen
GO:0098978 glutamatergic synapse
GO:1904813 ficolin-1-rich granule lumen

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Biological Process
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Cellular Component
External links
PDB RCSB:8a8m, PDBe:8a8m, PDBj:8a8m
PDBsum8a8m
PubMed37708276
UniProtQ16539|MK14_HUMAN Mitogen-activated protein kinase 14 (Gene Name=MAPK14)

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