Structure of PDB 7zyf Chain A Binding Site BS02

Receptor Information
>7zyf Chain A (length=852) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNI
ILHSTGHNISRVTFMSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKI
EYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAF
KATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAF
IVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQ
YPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKI
IAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDF
LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKT
YLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTTLDVKRMMKTWTLQ
KGFPLVTVQKKGKELFIQQERFFLNSYLWHIPLSYVTEGRNYSKYQSVSL
LDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVL
SDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD
LIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSAL
LEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKG
WSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQK
LSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYL
FSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTW
WL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7zyf Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zyf Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		H464 H468 E487
Binding residue
(residue number reindexed from 1)		H303 H307 E326
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zyf, PDBe:7zyf, PDBj:7zyf
PDBsum7zyf
PubMed35833347
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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