Structure of PDB 7zo2 Chain A Binding Site BS02

Receptor Information
>7zo2 Chain A (length=265) Species: 40324 (Stenotrophomonas maltophilia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLL
DGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGA
KVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVF
TAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHL
IEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADA
AEQKFDGQLAKETAG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7zo2 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zo2 Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
Resolution1.49 Å
Binding residue
(original residue number in PDB)		H84 H86 H160
Binding residue
(residue number reindexed from 1)		H82 H84 H158
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:7zo2, PDBe:7zo2, PDBj:7zo2
PDBsum7zo2
PubMed36924941
UniProtP52700|BLA1_STEMA Metallo-beta-lactamase L1 type 3

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