Structure of PDB 7z5a Chain A Binding Site BS02

Receptor Information
>7z5a Chain A (length=264) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSAPMNADSGWKLLRLFN
GYVYSGVETLGKELFMYFGHRALRIHFGMKGSILINPRGASPALAVQLTR
DLICFYDSSVELRNSVESQQRVREMEELDICSPKFSFSRAESEVKKQGDR
MLCDVLLDQRVLPGVGNIIKNEALFDSGLHPAVKVCQLSDKQARHLVKMT
RDFSILFYRCCKAGSAISKHCKVYKRPNCGQCHSKITVCRFGENSRMTYF
CPHCQKDGLEVLFQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z5a Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z5a Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		C255 C258 C277 C280
Binding residue
(residue number reindexed from 1)		C229 C232 C251 C254
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7z5a, PDBe:7z5a, PDBj:7z5a
PDBsum7z5a
PubMed36155818
UniProtQ8K203|NEIL3_MOUSE Endonuclease 8-like 3 (Gene Name=Neil3)

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