Structure of PDB 7z3j Chain A Binding Site BS02

Receptor Information
>7z3j Chain A (length=1119) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADK
IEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLK
TLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRDITYGQFAQLYRSLMYSAQKTMDLPF
LELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYF
FLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQ
FSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDV
LHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVD
IAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNG
ILYLEDPVNHEWYPHYFVLTSSKIYYSEETSLHSSEKWFHGKLGAGRDGR
HIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHS
RQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNA
HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKI
KHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALE
KIGSGSTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYG
GKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIA
IRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTAD
KKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAK
GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP
MQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLG
ARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFH
FQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNY
SEDLELASLLIKIDIFPAK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7z3j Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z3j Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E351 R355
Binding residue
(residue number reindexed from 1)		E308 R312
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0009395 phospholipid catabolic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7z3j, PDBe:7z3j, PDBj:7z3j
PDBsum7z3j
PubMed35749497
UniProtP10686|PLCG1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Gene Name=Plcg1)

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