Structure of PDB 7z36 Chain A Binding Site BS02

Receptor Information
>7z36 Chain A (length=433) Species: 9606,10665 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQGNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKS
ELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAV
RRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSIWYNQTPN
RAKRVITTFRTGTWDAYAAEALELLEHCGVCRERLRPEREPRLLPCLHSA
CSACLTVVDCPVCKQQCFSKDIVENYFMYCNVHKHEPLVLFCESCDTLTC
RDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRS
SIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLE
RQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMI
VDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAER
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z36 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z36 Structure and functional mapping of the KRAB-KAP1 repressor complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C196 C199 C219
Binding residue
(residue number reindexed from 1)		C178 C181 C201
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z36, PDBe:7z36, PDBj:7z36
PDBsum7z36
PubMed36341546
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
Q13263|TIF1B_HUMAN Transcription intermediary factor 1-beta (Gene Name=TRIM28)

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