Structure of PDB 7z1q Chain A Binding Site BS02

Receptor Information

>7z1q Chain A (length=191) Species: 4081 (Solanum lycopersicum)

STITTHHLTVPPGLTPEEFQELSSSIAEFHSYRINPGQCSSLLAQRIHAP
VETVWTVVRRFDKPQTYKHFIKSCSVGEDFRMTVGSTRDVTVISGLPAAT
STERLDILDDDRHVTGFSIIGGDHRLRNYRSVTTVHGFERDGEIWTVVLE
SYVVDVPEGNTEEDTRLFADTVVKLNLQKLASVTETLAREA

Ligand information

• Ligand ID: NIO
• InChI: InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: O=C(O)c1cccnc1
  OpenEye OEToolkits 1.5.0: c1cc(cnc1)C(=O)O
  CACTVS 3.341: OC(=O)c1cccnc1
• Formula: C6 H5 N O2
• Name: NICOTINIC ACID
• ChEMBL: CHEMBL573
• DrugBank: DB00627
• ZINC: ZINC000000001795
• PDB chain: 7z1q Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z1q Structure-Based Modulation of the Ligand Sensitivity of a Tomato Dimeric Abscisic Acid Receptor Through a Glu to Asp Mutation in the Latch Loop.
• Resolution: 1.683 Å
• Binding residue (original residue number in PDB): F98 S122 R153 F196
• Binding residue (residue number reindexed from 1): F70 S94 R125 F168
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004864 protein phosphatase inhibitor activity
• GO:0010427 abscisic acid binding
• GO:0038023 signaling receptor activity

Biological Process

• GO:0009738 abscisic acid-activated signaling pathway

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:7z1q, PDBe:7z1q, PDBj:7z1q
• PDBsum: 7z1q
• PubMed: 35734246
• UniProt: A0A3Q7HTY9