Structure of PDB 7yzx Chain A Binding Site BS02

Receptor Information
>7yzx Chain A (length=930) Species: 1314 (Streptococcus pyogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLT
DKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEH
GTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYA
QAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSA
GNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATV
KTDDHQAKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIER
GDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDG
LLLKDNSKKTITFNATPKVLPTASDTKLSRFSSWGLTADGNIKPDIAAPG
QDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLD
LAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNT
SSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPK
ALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFK
QDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQ
LDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIESSEITETIFAG
TFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLV
AEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGK
VVVNGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRR
LTLASKPKTSQPIYRERIAYTYMDEDPTTEYISPNEDGTFTLPEEAETGT
VPLKMSDFTYVVEDMAGNITYTPVTKLLEG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7yzx Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yzx X-ray diffraction data for the C5a-peptidase mutant with modified activity and specificity.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S822 N824 D826 N828 D830
Binding residue
(residue number reindexed from 1)		S726 N728 D730 N732 D734
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yzx, PDBe:7yzx, PDBj:7yzx
PDBsum7yzx
PubMed36478677
UniProtP15926|C5AP_STRPY C5a peptidase (Gene Name=scpA)

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