Structure of PDB 7yzp Chain A Binding Site BS02

Receptor Information
>7yzp Chain A (length=381) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRILHTSDWHLGQNFYSKSREAEHQAFLDWLLETAQTHQVDAIIVAGDVF
DTGSPPSYARTLYNRFVVNLQQTGCHLVVLAGNQDSVATLNESRDIMAFL
NTTVVASAGHAPQILPRRDGTPGAVLCPIPFLRPRDIITSQAGLNGIEKQ
QHLLAAITDYYQQHYADACKLRGDQPLPIIATGHLTTVTLDAFPAQNFPP
ADYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGKSKYVHLVTFSNGK
LESVENLNVPVTQPMAVLKGDLASITAQLEQWRDVSQEPPVWLDIEITTD
EYLHDIQRKIQALTESLPVEVLLVRRSREQRERVLASQQRETLSELSVEE
VFNRRLALEELDESQQQRLQHLFTTTLHTLA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7yzp Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yzp Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		D8 H10 D48 H224
Binding residue
(residue number reindexed from 1)		D8 H10 D48 H210
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:1990238 double-stranded DNA endonuclease activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yzp, PDBe:7yzp, PDBj:7yzp
PDBsum7yzp
PubMed35987200
UniProtP0AG76|SBCD_ECOLI Nuclease SbcCD subunit D (Gene Name=sbcD)

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