Structure of PDB 7yzi Chain A Binding Site BS02

Receptor Information
>7yzi Chain A (length=378) Species: 555461 (Mycobacterium tuberculosis '98-R604 INH-RIF-EM') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIV
PLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLL
VGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSA
CGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER
NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQH
GLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNP
VPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPD
EVYERLKDDFVLRERMRTWYLIGRKVAA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7yzi Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yzi Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
Resolution3.83 Å
Binding residue
(original residue number in PDB)		D256 I257 D300
Binding residue
(residue number reindexed from 1)		D216 I217 D260
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001653 peptide receptor activity
GO:0004016 adenylate cyclase activity
GO:0004383 guanylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0006182 cGMP biosynthetic process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yzi, PDBe:7yzi, PDBj:7yzi
PDBsum7yzi
PubMed35980026
UniProtP9WQ35|CYA1_MYCTU Adenylate cyclase (Gene Name=cya)

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