Structure of PDB 7yul Chain A Binding Site BS02

Receptor Information
>7yul Chain A (length=92) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQIEKWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKA
VKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTK
Ligand information
Ligand IDGOA
InChIInChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
InChIKeyAEMRFAOFKBGASW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CO
OpenEye OEToolkits 1.7.0C(C(=O)O)O
CACTVS 3.370OCC(O)=O
FormulaC2 H4 O3
NameGLYCOLIC ACID;
HYDROXYACETIC ACID;
HYDROXYETHANOIC ACID
ChEMBLCHEMBL252557
DrugBankDB03085
ZINCZINC000004658557
PDB chain7yul Chain C Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yul Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
Resolution1.82 Å
Binding residue
(original residue number in PDB)		S216 S217
Binding residue
(residue number reindexed from 1)		S43 S44
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
Biological Process
GO:0045666 positive regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yul, PDBe:7yul, PDBj:7yul
PDBsum7yul
PubMed37086783
UniProtQ5SZJ8|BEND6_HUMAN BEN domain-containing protein 6 (Gene Name=BEND6)

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