Structure of PDB 7ytw Chain A Binding Site BS02

Receptor Information
>7ytw Chain A (length=507) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMV
SQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKC
PSEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGAL
LSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLR
NLTIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIM
AISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAG
APPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR
RVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNL
QFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLL
TTEMFVGGCLAFILDNTVPGSPEERGLIQWSYDFPFGMGMVKRTTFFRYI
PICPVFR
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7ytw Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ytw Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		I202 E341
Binding residue
(residue number reindexed from 1)		I166 E287
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008520 L-ascorbate:sodium symporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015229 L-ascorbic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0007420 brain development
GO:0009636 response to toxic substance
GO:0015747 urate transport
GO:0015882 L-ascorbic acid transmembrane transport
GO:0030324 lung development
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0043229 intracellular organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ytw, PDBe:7ytw, PDBj:7ytw
PDBsum7ytw
PubMed36914666
UniProtQ9Z2J0|S23A1_MOUSE Solute carrier family 23 member 1 (Gene Name=Slc23a1)

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