Structure of PDB 7ytl Chain A Binding Site BS02

Receptor Information
>7ytl Chain A (length=363) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRVVIVGGGFGGIAAASQLKSWAVPFVLVDMRDAFHHNVAALRASVESGF
ARKTFISYSVTFGDSFRQGKVVGIDPERQQVLLSDGEELHYSHLILATGS
DGPFPGKFNKVIDMESAIQTYEDMVKEIEKSERILVVGGGAAGVEMAAEI
KTEYPAKEVTLIHSKIALADVELLQSVRQEVKEILLRKGVRLLLSEKVSN
VENLTTNQFQKDMVVRTEKGTEVVVDMVVLCTGIKINSSAYATAFGDKLA
SNGALNVNKHLQLEGYDNIYAIGDCANLKEPKMAYHAELHANIVVSNIIN
SLTHKPLKTYQPGSLTFLLSMGKNDGVGQVKGYYVGHLLVTIAKSRDLFV
SKSWKTMGQPMPS
Ligand information
Ligand IDUQ1
InChIInChI=1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3
InChIKeySOECUQMRSRVZQQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C
OpenEye OEToolkits 1.5.0CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)C
ACDLabs 10.04O=C1C(=C(C(=O)C(OC)=C1OC)C)C\C=C(/C)C
FormulaC14 H18 O4
NameUBIQUINONE-1
ChEMBLCHEMBL1236594
DrugBankDB08689
ZINCZINC000001559692
PDB chain7ytl Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ytl Structural insights into FSP1 catalysis and ferroptosis inhibition.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		Y295 F327 F359
Binding residue
(residue number reindexed from 1)		Y285 F317 F349
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006743 ubiquinone metabolic process
GO:0008637 apoptotic mitochondrial changes
GO:0022904 respiratory electron transport chain
GO:0042373 vitamin K metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0110076 negative regulation of ferroptosis
GO:1990748 cellular detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ytl, PDBe:7ytl, PDBj:7ytl
PDBsum7ytl
PubMed37739943
UniProtE1BR24

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