Structure of PDB 7ync Chain A Binding Site BS02

Receptor Information
>7ync Chain A (length=1536) Species: 45657 (Desulfonema ishimotonii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNT
KGRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQ
LRQRSTLRWTDKNPCPDNAETYCPFCELLGRRFRIHFGNLSLPGKPDFDG
PKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDNKVSAE
ARKLLCDSLKFTDRLCGALCVIRFDNLAEKTAEQIISILDDNKKTEYTRL
LADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGKKKKDENSVTIRQILT
TSADTKELKNAGKWREFCEKLGEALYLKSKDMDAEFHGKPDRLEKSRSVS
IGSVLKETVVCGELVAKTPFFFGAIDEDAKQTDLQVLLTPDNKYRLPRSA
VRGILRRDLQTYFDSPCNAELGGRPCMCKTCRIMRGITVMDARSEYNAPP
EIRHRTRINPFTGTVAEGALFNMEVAPEGIVFPFQLRYRGSEDGLPDALK
TVLKWWAEGQAFMSGAASTGKGRFRMENAKYETLDLSDENQRNDYLKNWG
WRDEKGLEELKKRLNSGLPEPGNYRDPKWHEINVSIEMASPFINGDPIRA
AVDKRGTDVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAVARIHMEDGV
PLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPVTFDHVAIDR
FTGGAADKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEEYCKALGKAL
ADVNNGLYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNPAFDETDVAVPE
KPKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFHEGRLTGKIR
CKLITKTPLIVPDTSNDDFFRPADKEARKEKDEYHKSYAFFRLHKQIMIP
GSELRGMVSSVYETVTNSCFRIFDETKRLSWRMDADHQNVLQDFLPGRVT
ADGKHIQKFSETARVPFYDKTQKHFDILDEQEIAGEKPVRMWVKRFIKRL
SLVDPAKHPQKKQDNKWKRRKEGIATFIEQKNGSYYFNVVTNNGCTSFHL
WHKPDNFDQEKLEGIQNGEKLDCWVRDSRYQKAFQEIPENDPDGWECKEG
YLHVVGPSKVEFSDKKGDVINNFQGTLPSVPNDWKTIRTNDFKNRKRKNE
PVFCCEDDKGNYYTMAKYCETFFFDLKENEEYEIPEKARIKYKELLRVYN
NNPQAVPESVFQSRVARENVEKLKSGDLVYFKHNEKYVEDIVPVRISRTV
DDRMIGKRMSADLRPCHGDWRHPKGLCPACRLFGTGSYKGRVRFGFASLE
NDPEWLIPGKNPGDPFHGGPVMLSLLERPRPTWSIPGSDNKFKVPGRKFY
VHHHAWKTIKDGNHPTTGKAIEQSPNNRTVEALAGGNSFSFEIAFENLKE
WELGLLIHSLQLEKGLAHKLGMAKSMGFGSVEIDVESVRLRKDWKQWRNG
NSEIPNWLGKGFAKLKEWFRDELDFIENLKKLLWFPEGDQAPRVCYPMLR
KKDDPNGNSGYEELKDGEFKKEDRQKKLTTPWTPWA
Ligand information
>7ync Chain C (length=28) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaguaacgauguuguucaaguuccucaa
............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ync Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		R283 D379 E513 G514 L516 F517 D654 E717 Y718 K754 K756 F757 A981 D982 H983 R1125 E1157 Q1250 L1390 N1441 L1564 R1565
Binding residue
(residue number reindexed from 1)		R249 D333 E467 G468 L470 F471 D608 E671 Y672 K708 K710 F711 A935 D936 H937 R1079 E1111 Q1204 L1325 N1376 L1499 R1500
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:7ync, PDBe:7ync, PDBj:7ync
PDBsum7ync
PubMed36702942
UniProtA0A401FT36

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