Structure of PDB 7yi5 Chain A Binding Site BS02

Receptor Information
>7yi5 Chain A (length=506) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSN
KELFTWFKNFVGYQEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVG
HPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETI
VNKIENSMTIYKKVIRKVYDKERGFEIIDALHETAPVVLKRLKQKDEEWR
RAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEISSIK
VDQTNKKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLK
YFISLFFSISFEKIEESSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNE
RVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLIN
GDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIM
ALFVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQY
IALDDL
Ligand information
>7yi5 Chain P (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atgcacaggatgtatatatctgacacgtgcctggagactagggagtaatc
cccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggt
gctagagctgtctacgaccaattgagcggcctgcagaccgggattctcca
g
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yi5 Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		Q937 K941
Binding residue
(residue number reindexed from 1)		Q231 K235
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0016479 negative regulation of transcription by RNA polymerase I
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0034605 cellular response to heat
GO:0044804 nucleophagy
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation
GO:0061188 negative regulation of rDNA heterochromatin formation
GO:0070550 rDNA chromatin condensation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0032221 Rpd3S complex
GO:0033698 Rpd3L complex
GO:0070210 Rpd3L-Expanded complex
GO:0070822 Sin3-type complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yi5, PDBe:7yi5, PDBj:7yi5
PDBsum7yi5
PubMed37468628
UniProtP22579|SIN3_YEAST Transcriptional regulatory protein SIN3 (Gene Name=SIN3)

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