Structure of PDB 7yhq Chain A Binding Site BS02

Receptor Information
>7yhq Chain A (length=393) Species: 3702,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPFVRSTMDTVDWKAIRAADVKEVAETIKSRGM
NHKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSV
ECVRLLTLHHLAFPVDTNVGRIAVRLGWVPLQPLPESLQLHLLEMYPMLE
SIQKYLWPRLCKLDQKTLYELHYQMITFGKVFCTKSKPNCNACPMKGECR
HFASAFSQLRTEHRVYELPDEHPLLAQLEKREPDDPCSYLLAIWVRGTIL
IPCRTAMRGSFPLNGTYFQVNEVFADHASSLNPINVPIWELPRRTVYFGT
SVPTIFKGLSTEKIQACFWKGYVCVRGFDRKTRGPKPLIARLH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yhq Molecular basis of the plant ROS1-mediated active DNA demethylation.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		T606 Q607 N608 V609 S610 D611 R912 G949 L950 G951 K953 S954 D971 T972 N973 K1035 K1040
Binding residue
(residue number reindexed from 1)		T47 Q48 N49 V50 S51 D52 R107 G144 L145 G146 K148 S149 D166 T167 N168 K230 K235
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0019104 DNA N-glycosylase activity
GO:0035514 DNA demethylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yhq, PDBe:7yhq, PDBj:7yhq
PDBsum7yhq
PubMed36624257
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q9SJQ6

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