Structure of PDB 7yhp Chain A Binding Site BS02

Receptor Information
>7yhp Chain A (length=374) Species: 3702,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPRSTMDTVDWKAIRAADVKEVAETIKSRGMNH
KLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSVEC
VRLLTLHHLAFPVNTNVGRIAVRLGWVESIQKYLWPRLCKLDQKTLYELH
YQMITFGKVFCTKSKPNCNACPMKGECRHFASAFSQLRTEHRVYELPDEH
PLLAQLEKREPDDPCSYLLAIWVRGTILIPCRTAMRGSFPLNGTYFQVNE
VFADHASSLNPINVPRELIWELPRRTVYFGTSVPTIFKGLSTEKIQACFW
KGYVCVRGFDRKTRGPKPLIARLH
Ligand information
Receptor-Ligand Complex Structure
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PDB7yhp Molecular basis of the plant ROS1-mediated active DNA demethylation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Q607 V609 S610 D611 R912 N948 G949 G951 S954 N971 T972 H1027 I1031 T1299 Y1300
Binding residue
(residue number reindexed from 1)		Q48 V50 S51 D52 R105 N141 G142 G144 S147 N164 T165 H200 I204 T294 Y295
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0019104 DNA N-glycosylase activity
GO:0035514 DNA demethylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yhp, PDBe:7yhp, PDBj:7yhp
PDBsum7yhp
PubMed36624257
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q9SJQ6

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