Structure of PDB 7yho Chain A Binding Site BS02

Receptor Information
>7yho Chain A (length=361) Species: 3702,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPFVSTMDTVDWKAIRAADVKEVAETIKSRGMN
HKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSVE
CVRLLTLHHLAFPVNTNVGRIAVRLGWVEMYPMLESIQKYLWPRLCKLDQ
KTLYELHYQMITFGKVFCTKSKPNCNACPMKGECRHFASAFHRVYELPDE
HPLLAQLEKREPDDPCSYLLAIWGTILIPCRTAMRGSFPLNGTYFQVNEV
FADHASSLNPINVPPRRTVYFGTSVPTIFKGLSTEKIQACFWKGYVCVRG
FDRKTRGPKPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yho Molecular basis of the plant ROS1-mediated active DNA demethylation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q607 N608 D611 R912 N948 G949 G951 K953 S954 N971 I1031
Binding residue
(residue number reindexed from 1)		Q48 N49 D52 R106 N142 G143 G145 K147 S148 N165 I211
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0019104 DNA N-glycosylase activity
GO:0035514 DNA demethylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yho, PDBe:7yho, PDBj:7yho
PDBsum7yho
PubMed36624257
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q9SJQ6

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