Structure of PDB 7yh4 Chain A Binding Site BS02

Receptor Information
>7yh4 Chain A (length=400) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFQGSLELLKLRSAECIDEAAERLGALSRAIWSQPELAYEEHHAHRVLT
HFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARPRPLHLGFLCEYDALP
GIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLGTPAEEDGG
GKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSA
SYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSY
SELIYYFRAPSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVL
PNKSLWKAYMENGRKLGIEFIGSTDFGNVSFVVPGIHPYFHIGSNALNHT
EQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yh4 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yh4 Crystal structure of human cytosolic beta-alanyl lysine dipeptidase (PM20D2)
Resolution2.03 Å
Binding residue
(original residue number in PDB)
H126 H189
Binding residue
(residue number reindexed from 1)
H108 H171
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.13.4: Xaa-Arg dipeptidase.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016805 dipeptidase activity
GO:0042802 identical protein binding
GO:0071713 para-aminobenzoyl-glutamate hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0046657 folic acid catabolic process
GO:0051246 regulation of protein metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7yh4, PDBe:7yh4, PDBj:7yh4
PDBsum7yh4
PubMed
UniProtQ8IYS1|P20D2_HUMAN Xaa-Arg dipeptidase (Gene Name=PM20D2)

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