Structure of PDB 7ygn Chain A Binding Site BS02

Receptor Information
>7ygn Chain A (length=739) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGSKGTPQSLGLNLIKIQCHNEAVYQYHVTFSPSVECKSMRFGMLKDHQS
VTGNVTAFDGSILYLPVKLQQVVELKSQRKTDDAEISIKIQLTKILEPCS
DLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAAS
IRRTDGGLFLLADVSHKVIRNDSVLDVMHAIYQQNKEHFQDECSKLLVGS
IVITRYNNRTYRIDDVDWNKTPKDSFVEITFLEYYSKNYGITVKEDDQPL
LIHRPEILLLPELSFMTGIPEKMKKDFRAMKDLTQQINLSPKQHHGALEC
LLQRISQNETASNELTRWGLSLHKDVHKIEGRLLPMERINLRNTSFVTSE
DLNWVKEVTRDASILTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGM
RISPPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDLYGAI
KKLCCVQSPVPSQVINVRTIGQPTRLRSVAQKILLQMNCKLGGELWGVDI
PLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMPHQEI
VDSLKLCLVGSLKKYYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQ
KCFEAFDNYHPKMVVFVVQKKISTNLYLAAPDHFVTPSPGTVVDHTITSC
EWVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFKLCHMYWNW
PGTIRVPAPCKYAHKLAFLSGQILHHEPAIQLCGNLFFL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ygn Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ygn Structure basis of mammalian Piwi-piRNA silencing machinery
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q718 L971
Binding residue
(residue number reindexed from 1)		Q486 L739
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:7ygn, PDBe:7ygn, PDBj:7ygn
PDBsum7ygn
PubMed38658622
UniProtQ8CDG1|PIWL2_MOUSE Piwi-like protein 2 (Gene Name=Piwil2)

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