Structure of PDB 7y7q Chain A Binding Site BS02

Receptor Information

>7y7q Chain A (length=951) Species: 5141 (Neurospora crassa)

APVVAARLRNIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLEDESGLKYD
PSWSTARDVTDIWKTLYLDAFRPEKPPNDVFVTAMTGNFESKGSAVVLSA
VLDYNPDNSPTAPLYLVKLKPLMFEQGCRLTRRFGPDRFFEILIPSPTST
SPSVPPVVSKQGAVEEVIQWLTMGQHSLVGRQWRAFFAKDAGYRKPLREF
QPKPIIKERVHFFAETGITFRPEPVEQRTEFKVSQMLDWLLQLDNNTWQP
HLKLFSRIQLGLSKTYAIMTLEPHQIRHHKTDLLSPSGTGEVMNDGVGRM
SRSVAKRIRDVLGLGDVPSAVQGRFGSAKGMWVIDVDDTGDEDWIETYPS
QRKWECDFVDKHQRTLEVRSVASELKSAGLNLQLLPVLEDRARDKVKMRQ
AIGDRLINDLQRQFSEQKHALNRPVEFRQWVYESYSSRATRVSHGRVPFL
AGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQKRKCDTLKSKLNIRV
GRSAYIYMIADFWGVLEENEVHVGFSSKFRDEEESFTLLSDCDVLVARSP
AHFPSDIQRVRAVFKPELHSLKDVIIFSTKGDVPLAKKLSGGDYDGDMAW
VCWDPEIVDGFVNAEMPLEPDLSRYLKKDKTTFKQLMASHGTGSAAKEQT
TYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVSNKPAIILSSLVGNL
VDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSDSWLGRGEPTHIID
YLKFSIARPAIDKELEAFHNAAHFWDPDLASYYTFFKEISDKSRSSALLF
TTLKNRIGEVEKEYGRLVKNSKDPYPVRVNQVYEKWCAITPESKVIRLLE
LSFLADREMNTWALLRASTAFKLYYHKSPKFVWQMAGRQLAYIKAQMTSR
PGEGAPALMTAFMYAGLMPDKKFTKQYVARLEEYPDPEVYDGIGFTGNGD
Y

Ligand information

>7y7q Chain D (length=7)

uccgacg

.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7q Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): R591 S677 K678 Q736 R783 S963 D1011
• Binding residue (residue number reindexed from 1): R194 S263 K264 Q322 R369 S549 D597

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

External links

• PDB: RCSB:7y7q, PDBe:7y7q, PDBj:7y7q
• PDBsum: 7y7q
• PubMed: 36039765
• UniProt: Q9Y7G6