Structure of PDB 7y5h Chain A Binding Site BS02

Receptor Information
>7y5h Chain A (length=300) Species: 8364 (Xenopus tropicalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYHCHNNNKKAYDARQREQTFAKKKLCIASLICFVFISAEIVGGYILAVV
TDAAHLLVDLSSFFISLCSLWLSSKSSTTRLTFGWHRAEILGALMSVITI
WLVTGVLVYLACERLIRPDTVMLITSACALGANLVLALILHKPQTNASIR
AAFIHVIGDLFQSISVLISALIIYFKPEYKMADPICTFIFSIFVLITTVT
VLRDLLTVLMEGTPRGIHYSDVKQSILAVDGVKSVHSLHLWALTMNQVIL
SAHIATDIVGESKRILKDVTQNVFARFPFHSVTIQVEPIEDQSPECMFCY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7y5h Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7y5h Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn 2+ -releasing mechanism.
Resolution3.72 Å
Binding residue
(original residue number in PDB)		H306 H323 E357
Binding residue
(residue number reindexed from 1)		H236 H253 E287
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015297 antiporter activity
GO:0046872 metal ion binding
GO:0140826 zinc:proton antiporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0055085 transmembrane transport
GO:0062111 zinc ion import into organelle
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7y5h, PDBe:7y5h, PDBj:7y5h
PDBsum7y5h
PubMed36464198
UniProtQ5XHB4|ZNT8_XENTR Proton-coupled zinc antiporter SLC30A8 (Gene Name=slc30a8)

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