Structure of PDB 7y1n Chain A Binding Site BS02

Receptor Information
>7y1n Chain A (length=1171) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKE
AYEEQKKKAPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQ
RVNESKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLA
MIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPV
QIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST
ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLS
IFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLS
TVVRFAVKAIISVQKLNEFLLSDEDVAIKVTNGYFSWGSGLATLSNIDIR
IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNSRYSVAYAAQKP
WLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERG
INLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFL
QDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEH
WKTLMNRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWL
ATWTSEYQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLN
KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSA
IGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH
FSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTD
YLGACIVLTASIASISSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGA
VKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPV
LKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS
KLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLK
NMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATAS
IDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYD
TPESLLAQEDGVFASFVRADM
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7y1n Chain A Residue 3003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y1n The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Resolution3.61 Å
Binding residue
(original residue number in PDB)		S708 Q753
Binding residue
(residue number reindexed from 1)		S418 Q448
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0015459 potassium channel regulator activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0019905 syntaxin binding
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0099104 potassium channel activator activity
GO:0140359 ABC-type transporter activity
GO:1901363 heterocyclic compound binding
Biological Process
GO:0000165 MAPK cascade
GO:0001508 action potential
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0003007 heart morphogenesis
GO:0003018 vascular process in circulatory system
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006813 potassium ion transport
GO:0006932 substrate-dependent cell migration, cell contraction
GO:0006950 response to stress
GO:0007005 mitochondrion organization
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009410 response to xenobiotic stimulus
GO:0010467 gene expression
GO:0014823 response to activity
GO:0019395 fatty acid oxidation
GO:0033198 response to ATP
GO:0035864 response to potassium ion
GO:0035865 cellular response to potassium ion
GO:0036293 response to decreased oxygen levels
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0042542 response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045333 cellular respiration
GO:0045776 negative regulation of blood pressure
GO:0046034 ATP metabolic process
GO:0048144 fibroblast proliferation
GO:0051607 defense response to virus
GO:0055085 transmembrane transport
GO:0060976 coronary vasculature development
GO:0061337 cardiac conduction
GO:0062197 cellular response to chemical stress
GO:0070482 response to oxygen levels
GO:0071277 cellular response to calcium ion
GO:0071318 cellular response to ATP
GO:0071466 cellular response to xenobiotic stimulus
GO:0071805 potassium ion transmembrane transport
GO:0072359 circulatory system development
GO:0072592 oxygen metabolic process
GO:0086003 cardiac muscle cell contraction
GO:0097746 blood vessel diameter maintenance
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901652 response to peptide
GO:1903409 reactive oxygen species biosynthetic process
GO:1904880 response to hydrogen sulfide
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030315 T-tubule
GO:0031004 potassium ion-transporting ATPase complex
GO:0032991 protein-containing complex
GO:0042383 sarcolemma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7y1n, PDBe:7y1n, PDBj:7y1n
PDBsum7y1n
PubMed37330603
UniProtQ63563|ABCC9_RAT ATP-binding cassette sub-family C member 9 (Gene Name=Abcc9)

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