Structure of PDB 7y0i Chain A Binding Site BS02

Receptor Information
>7y0i Chain A (length=56) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGGRDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCD
PRPVDR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7y0i Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y0i Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.
ResolutionN/A
Binding residue
(original residue number in PDB)		C9 C11 H31 C34
Binding residue
(residue number reindexed from 1)		C9 C11 H31 C34
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
External links
PDB RCSB:7y0i, PDBe:7y0i, PDBj:7y0i
PDBsum7y0i
PubMed36033518
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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